The messing with the clocks which I have tied directly to the use of
BOINC 4.45 can really mess with some of the apps.

Another thing that contributes to timing slips on Windows is running
multi-media applications, as they cause the clock frequency to change,
greatly increasing the chance of lost interrupts.  You shouldn't run

It's not quite an hour (I've been doing this post in bits and pieces)
and the computer has lost well over a minute running 4.25 with no
active WUs and the CPU showing on the order of 1% utilization.  There
are no other apps running except the normal background stuff such as
firewall, bot checkers, AddAware, and NAV.